The Mechanisms of Cadmium Toxicity in Living Organisms Original paper

Researched by:

  • Divine Aleru ID
    Divine Aleru

    User avatarDivine Aleru is an accomplished biochemist and researcher with a specialized background in environmental toxicology, focusing on the impacts of heavy metals on human health. With deep-rooted expertise in microbiome signatures analysis, Divine seamlessly blends rigorous scientific training with her passion for deciphering the intricate relationships between environmental exposures and the human microbiome. Her career is distinguished by a commitment to advancing integrative health interventions, leveraging cutting-edge microbiome research to illuminate how toxic metals shape biological systems. Driven by curiosity and innovation, Divine is dedicated to translating complex environmental findings into actionable insights that improve individual and public health outcomes.

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October 1, 2025

Researched by:

  • Divine Aleru ID
    Divine Aleru

    User avatarDivine Aleru is an accomplished biochemist and researcher with a specialized background in environmental toxicology, focusing on the impacts of heavy metals on human health. With deep-rooted expertise in microbiome signatures analysis, Divine seamlessly blends rigorous scientific training with her passion for deciphering the intricate relationships between environmental exposures and the human microbiome. Her career is distinguished by a commitment to advancing integrative health interventions, leveraging cutting-edge microbiome research to illuminate how toxic metals shape biological systems. Driven by curiosity and innovation, Divine is dedicated to translating complex environmental findings into actionable insights that improve individual and public health outcomes.

    Read More

Last Updated: 2025-10-01

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Divine Aleru

Divine Aleru is an accomplished biochemist and researcher with a specialized background in environmental toxicology, focusing on the impacts of heavy metals on human health. With deep-rooted expertise in microbiome signatures analysis, Divine seamlessly blends rigorous scientific training with her passion for deciphering the intricate relationships between environmental exposures and the human microbiome. Her career is distinguished by a commitment to advancing integrative health interventions, leveraging cutting-edge microbiome research to illuminate how toxic metals shape biological systems. Driven by curiosity and innovation, Divine is dedicated to translating complex environmental findings into actionable insights that improve individual and public health outcomes.

What was issued?

The European Union (EU) issued regulation 2023/915, which focuses on limiting cadmium (Cd) exposure in the environment, particularly in food, water, and soil. This regulation aims to reduce the harmful effects of cadmium exposure, which has been linked to various health issues, such as kidney damage, bone diseases, and cancer. The directive sets maximum allowable concentrations (MACs) for cadmium in drinking water, soil, and food products, with a specific emphasis on reducing contamination from industrial sources like phosphate fertilizers. It also outlines enforcement mechanisms to ensure compliance and protect public health.

Who is affected?

The regulation directly impacts food manufacturers, environmental regulators, and public health authorities. Food manufacturers are required to monitor and manage cadmium levels in their products to ensure they do not exceed the established limits. Consumers, especially vulnerable populations such as children, pregnant women, and those with pre-existing health conditions, are at risk of exposure to harmful cadmium levels. Public health officials are tasked with overseeing the enforcement of these limits, ensuring that both industrial activities and food products meet the established safety standards to protect human health.

Most important findings

Cadmium exposure limits have been set in response to increasing concerns over its long-term health effects. The regulation stipulates strict maximum allowable concentrations for cadmium in water, soil, and food. It also focuses on reducing cadmium levels originating from phosphate fertilizers, a significant source of environmental contamination. The enforcement of these limits includes stringent monitoring of both industrial activities and food products, with penalties for non-compliance. For the food industry, the regulation demands enhanced product testing and sourcing practices to minimize cadmium contamination.

Key implications

This regulation poses both challenges and opportunities for the food industry. Manufacturers must ensure that their products adhere to the new cadmium limits, requiring robust testing protocols and improved sourcing practices. Failure to comply can result in product recalls, penalties, and harm to the company’s reputation. Public health is also significantly impacted, as prolonged exposure to cadmium can lead to severe health issues. The regulation reflects a growing global effort to combat heavy metal contamination in food and the environment, emphasizing the importance of sustainable practices and strict regulatory measures.

Citation

Davidova, S., Milushev, V., & Satchanska, G. (2024). The Mechanisms of Cadmium Toxicity in Living Organisms. Toxics, 12(12), 875. https://doi.org/10.3390/toxics12120875

Cadmium (Cd)

Cadmium is a persistent heavy metal that accumulates in kidneys and bones. Dietary sources include cereals, cocoa, shellfish and vegetables, while smokers and industrial workers receive higher exposures. Studies link cadmium to kidney dysfunction, bone fractures and cancer.